Function
Beta-ketoacyl carrier protein reductase (BKACPR) catalyzes the reaction of conversion of 3-hydroxyacyl-[acyl-carrier-protein] to 3-oxoacyl-[acyl-carrier-protein] while using NADPH as a reducing agent.
Disease
Relevance
Structural highlights
3D structures of beta-ketoacyl carrier protein reductase
Updated on 29-June-2014
Beta-ketoacyl ACPR
1i01 – EcBKACPR – Escherichia coli
1uzl, 3lls – MtBKACPR – Mycobacterium tuberculosis
1uzm, 2ntn – MtBKACPR (mutant)
2p68, 2pnf – BKACPR – Aquifex aeolicus
3f9i – BKACPR – Rickettsia prowazekii
3osu – BKACPR – Staphylococcus aureus
3rro – VcBKACPR – Vibrio cholerae
3u09 – VcBKACPR (mutant)
4ijk – HpBKACPR – Helicobacter pylori
4afn – PaBKACPR – Pseudomonas aeruginosa
4fd3 – yBKACPR - yeast
Beta-ketoacyl ACPR complex
1q7b – EcBKACPR + NADP
1q7c – EcBKACPR (mutant) + NADP
1uzn – MtBKACPR (mutant) + NADP
2b4q, 4ag3 – PaBKACPR + NADP
3rsh, 4io8 – VcBKACPR + NADP
4iin – HpBKACPR + NAD
4fda, 4hbg – yBKACPR + NADP
4bnt, 4bnu, 4bnv, 4bnw, 4bnx, 4bny, 4bnz, 4bo0, 4bo1, 4bo2, 4bo3, 4bo4, 4bo5, 4bo6, 4bo7, 4bo8, 4bo9 – PaBKACPR + inhibitor
Specialized BKACPR
3lmo – RpACPR – Rhodopseudomonas palustris
2kw2, 2ll8, 2lpk – RpACPR – NMR
Pimelyl ACPR
4etw – ACPR – Shigella flexneri
4nmw – ACPR – Samonella enterica
Enoyl ACPR
See Enoyl-Acyl-Carrier Protein Reductase
References
