Enoyl-CoA hydratase

Function

Enoyl-CoA hydratase (ECH) is part of the fatty acid metabolism. ECH hydrates the double bond between the second and third carbons in acyl-CoA. ECH1 or short-chain ECH is mitochondrial. ECH1 processes enoyl-CoA thioesters from C4 to C16.

Disease

Relevance

Structural highlights

3D structures of enoyl-CoA hydratase

Updated on 10-July-2014

1uiy, 1wz8 – ECH – Thermus thermophilus
2ppy – ECH – Geobacillus kaustophilus
3lke – ECH – Bacillus halodurans
3myb, 3njb, 3njd, 3pe8, 4qfe – ECH – Mycobacterium smegmatis
3oc7, 3p85, 3q1t – MaECH – Mycobacterium avium
4j2u – ECH – Rhodobacter sphaeroides
4jyl – ECH – Thermoplasma volcanium
3jfc – ECH – Polaromonas
4jsb – TfECH – Thermobifida fusca

Enoyl-CoA hydratase complexes

4fzw – ECH + epoxyphenylacetyl-CoA isomerase – Escherichia coli

4jvt – TfECH + acetyl-CoA
4omr – TfECH + acetoacetyl-CoA

Enoyl-CoA hydratase/isomerase

3p5m – MaECH
4jcs – ECH – Cupriavidus metallidurans
4k29 – ECH – Xanthobacter autotrophicus
4k3w – ECH – Marinobacter aquaeolei
4kpk – ECH – Shewanella pealeana
4jyj, 4og1 – NaECH – Novosphingobium aromaticivorans
4kd6 – ECH – Burkholderia graminis
3kqf, 3pea – ECH – Bacillus anthracis
3l3s – ECH – Ruegeria pomeroyi
3ot6 – ECH – Pseudomonas syringae
4hc8, 4fn7 – MtECH – Mycobacterium tuberculosis
4mou – ECH – Anthrobacter aurescens
4olq – ECH – Hyphomonas neptunium

Enoyl-CoA hydratase/isomerase complexes

4fn8 – MtECH + acetoacetyl-CoA

4fnb – MtECH + hydroxybutyryl-CoA
4fnd – MtECH + hydroxyhexanoyl-CoA

Enoyl-CoA hydratase 1

2hw5 – ECH1 - human
4jwv – NaECH1
1dub – rECH1 - rat

Enoyl-CoA hydratase 1 complexes

2dub – rECH1 + octanoyl-CoA

1ey3 – rECH1 + cinnamoyl-CoA
1mj3 – rECH + hexadienoyl-CoA

References