4-hydroxy-3-methylbut-2-enyl diphosphate reductase

Function

4-hydroxy-2-methylbut-2-enyl diphosphate reductase (IspH or HMBPP reductase) is an iron-sulfur containing protein. IspH converts 1-hydroxy-2-methylbut-2-enyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). IspH is involved in penicillin tolerance and participates in isoprenoid biosynthesis.

Disease

Relevance

Structural highlights

3D structures of 4-hydroxy-3-methylbut-2-enyl diphosphate reductase

Updated on 20-July-2014

IspH containing Fe3S4 cluster

3dnf – IspH – Aquifex aeolicus
3f7t – EcIspH + PPi + Pi – Escherichia coli
3utd – EcIspH + oxopentyl diphosphate
3kef – EcIspH + DMAPP
3kel – EcIspH + PPi
3kem – EcIspH + IPP
3szu, 3tof, 3t0g – EcIspH (mutant) + HMBPP
4muy, 4mv0 – EcIspH + pyridine-4-yl methyl trihydrogen diphosphate
4mv5 – EcIspH + chloropyridine-3-yl methyl trihydrogen diphosphate

IspH containing Fe4S4 cluster

3ke8, 3szl, 3szo – EcIspH + HMBPP
3ke9 – EcIspH + IPP
3urk – EcIspH + propionyl diphosphate
3utc, 3uv3, 3uv6, 3uv7, 3uwm, 4eb3 – EcIspH + HMBPP derivative
3zgl, 3zgn, 4h4c, 4h4d, 4h4e – EcIspH + inhibitor
4mux – EcIspH + pyridine-3-yl methyl trihydrogen diphosphate

References