Function
Isopentenyl-diphosphate delta-isomerase (IPPI) catalyzes the conversion of the un-reactive isopentenyl diphosphate (IPP) to the more reactive dimethylallyl diphosphate (DMAPP). 3,4-epoxy-3-methyl butyl diphosphate (EIPP) is an irreversible inhibitor of IPPI. IPPI participates in isoprenoid biosynthesis.
Disease
Relevance
Structural highlights
3D structures of isopentenyl-diphosphate delta-isomerase
Updated on 21-July-2014
1i9a, 2vnq – EcIPPI + Mn – Escherichia coli
1hx3 – EcIPPI (mutant) + Mn
1r67 – EcIPPI (mutant) + Mg
2g74 – EcIPPI (mutant) + Mg + Mn
1hzt – EcIPPI
1p0k – BsIPPI – Bacillus subtilis
1p0n – BsIPPI + FMN
1vcf – TtIPPI + FMN + Cd – Thermus thermophilus
1vcg – TtIPPI + FMN
2zru, 2zrv, 3vkj – SsIPPI + FMN – Sulfolobus shibatae
3hyq – IPPI – Salmonella enterica
3sr7 – IPPI – Streptococcus mutans
4n02 – IPPI + FMN – Streptococcus pneumoniae
Isopentenyl-diphosphate delta-isomerase complex
1nfs, 2vnp – EcIPPI + Mn + Mg + dimethylamino-ethyl diphosphate
1pvf – EcIPPI + Mn + Mg + diphosphate
1nfz, 1ppw, 1x84 – EcIPPI + Mn + Mg + EIPP
1ow2, 1x83, 2g73, 2b2k – EcIPPI (mutant) + Mn + Mg + EIPP
1ppv – EcIPPI + Mn + Mg + bromo-EIPP
1q54 – EcIPPI (mutant) + Mn + Mg + bromo-EIPP
3dh7 – TtIPPI + FMN + diphosphate
2zrw, 2zry – SsIPPI + FMN + IPP
3b05 – SsIPPI + FMN + Mg + IPP
2zrx, 2zrz – SsIPPI + FMN + DMAPP
3b06 – SsIPPI + FMN + Mg + DMAPP
3b03, 3b04 – SsIPPI + Mg + inhibitor
References
