5'-deoxy-5'-methylthioadenosine phosphorylase

Function

5’-deoxy-5’-methylthioadenosine phosphorylase (MTAP) catalyzes the reversible phosphorolysis of 5’-deoxy-5’-methylthioadenosine (MTA) to adenine and 5-methylthio-D-ribose-1-phosphate. This reaction is the principle source of adenine in human cells.

Disease

Relevance

MTAP is a potential target of chemotherapy. More than 20% of human various cancer cells do not show MTAP activity.

Structural highlights

3D structures of 5’-deoxy-5’-methylthioadenosine phosphorylase

Updated on 22-July-2014

3oze – hMTAP - human

4glf – ubMTAP – uncultured bacteria
4l5y – SmMTAP – Schistosoma mansoni

MTAP complex with adenine

1cb0 – hMTAP (mutant) + adenine
1wta – MTAP + adenine – Aeropyrum pernix
4l5c, 4l6i – SmMTAP + adenine

MTAP complex with MTA

1cg6 – hMTAP (mutant) + MTA
2a8y, 3t94 – MTAP + MTA – Sulfolobus solfataricus

MTAP complex with antibiotics

1sd1, 1sd2 – hMTAP + antibiotic
4l5a – SmMTAP + antibiotic

MTAP other complexes

3ozc, 3ozd – hMTAP + pCL-phenylthioDADMeImmA
4glj – ubMTAP + rhodamine
1k27 – hMTAP + transition state analog

References