This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Peptide nucleic acids (PNA) incorporating nucleic acid bases into an achiral polyamide backbone bind to DNA in a sequence-dependent manner. The structure of a PNA-ribonucleic acid (RNA) complex was determined with nuclear magnetic resonance methods. A hexameric PNA formed a 1:1 complex with a complementary RNA that is an antiparallel, right-handed double helix with Watson-Crick base pairing similar to the "A" form structure of RNA duplexes. The achiral PNA backbone assumed a distinct conformation upon binding that differed from previously proposed models and provides a basis for further structure-based design of antisense agents.
NMR solution structure of a peptide nucleic acid complexed with RNA.,Brown SC, Thomson SA, Veal JM, Davis DG Science. 1994 Aug 5;265(5173):777-80. PMID:7519361[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
↑ Brown SC, Thomson SA, Veal JM, Davis DG. NMR solution structure of a peptide nucleic acid complexed with RNA. Science. 1994 Aug 5;265(5173):777-80. PMID:7519361
