Function
Ets1 (E26 Transformation-Specific) is a proto-oncogene translation factor. Ets1 contributes to the regulation of cellular differentiation. Ets1 contains an ETS domain which is a helix-turn-helix DNA-binding domain which recognizes the sequence GGAA/T. The ETS domain is flanked by autoinhibitory domains. At the N-terminal, Ets1 contains a pointed domain (PNT) and a MAP kinase phosphorylation domain. PNT domain is related to SAM domains and contains 4 α-helices.
Disease
Relevance
Ets1 promotes invasive behavior in endothelial cells, smooth muscle cells and epithelial cancer cells.
Structural highlights
3D Structures of Ets1
Updated on 23-July-2014
1md0 – mETS1 ETS domain - mouse
1r36 – mETS1 ETS and autoinhibitory domains - NMR
2jv3, 2kmd – mETS1 PNT domain - NMR
1gvj – hETS1 ETS and autoinhibitory domains - human
Ets1 binary complexes
2nny – hETS1 + DNA
3mfk – hETS1 + stromelysin promoter DNA
3ri4 – hETS1 + TCR α promoter DNA
2stt, 2stw – hETS1 + DNA - NMR
1k79, 1k7a – mETS1 ETS domain + DNA containing GGAA - mouse
Ets1 ternary complexes
1mdm – mETS1 ETS domain + paired box protein Pax5 + MB-1 promoter DNA
1k78 – hETS1 ETS domain + paired box protein Pax5 + MB-1 promoter DNA - NMR
4l0y, 4l0z, 4l18 – hETS1 + TCR α promoter DNA + RunT-related transcription factor
4lg0 – hETS1 + cadherin promoter DNA + forkhead box protein
References
