Tryptophan RNA-binding attenuation protein

Function

Tryptophan RNA-binding attenuation protein (TRAP) is a tryptophan-activated RNA-binding protein which regulates the expression of the tryptophan biosynthesis genes. TRAP is composed of 11 identical subunits arranged in a symmetrical ring. Down regulation of Trp biosynthesis is observed upon binding of 11 Trp to TRAP.

Disease

Relevance

Structural highlights

3D Structures of tryptophan RNA-binding attenuation protein

Updated on 29-July-2014

3aqd – GsTRAP – Geobacillus stearothermophilus

TRAP complex with Trp

2zdo, 2exs, 2ext, 2zcz, 2zd0 – GsTRAP + Trp
1wap, 3zzq – BsTRAP + Trp – Bacillus subtilis
4b27 – BsTRAP (mutant) + Trp
3zte – TRAP + Trp – Bacillus licheniformis
3zzl – TRAP + Trp – Bacillus halodurans

TRAP ternary complex with Trp

1c9s, 1gtf, 1gtn, 1utd, 1utf, 1utv – GsTRAP + RNA + Trp
2zp8, 2zp9 – GsTRAP + TRAP inhibitory protein + Trp

References