Adenosine deaminase (ADA) deaminates adenosine and deoxyadenosine into inosine or deoxyinosine. ADA is part of the purine metabolism. In humans ADA is involved in the development and maintenance of the immune system. ADA deficiency is the cause of severe combined immunodeficiency (SCID). SCID was the first disorder to be treated by gene therapy. There are 2 isoforms of ADA: ADA1 and ADA2. ADA contains Zn+2 ion in its active site.
3D Structures of adenosine deaminase
Updated on 31-July-2014
1vfl – bADA + Zn - bovine
3iar – hADA + Ni - human
3mvt – mADA – mouse
3mvi – mADA + Zn
3ou8 – PaADA + Zn – Pseudomonas aeruginosa
2amx – ADA + Co – Plasmodium yoeli
Adenosine deaminase complex with nucleotide
1add – mADA + Zn + deaza-adenosine
3km8 – mADA (mutant) + Zn + deaza-adenosine
2ada – mADA + Zn + transition state analog
1fkw, 1fkx, 1uio, 1uip – mADA (mutant) + Zn + adenosine analog
1a4m – mADA + Zn + adenosine analog
1krm – bADA + Zn + adenosine analog
2pgf – PvADA + Zn + adenosine – Plasmodium vivax
2pgr – PvADA + Zn + adenosine analog
2qvn – PvADA + guanosine
3pan – PaADA + Zn + hypoxanthine
3pao – PaADA + Zn + adenine
Adenosine deaminase complex with inhibitor
1a4l – mADA + Zn + inhibitor
1ndv, 1ndw, 1ndy, 1ndz, 1o5r, 1qxl, 1uml, 1v79, 1v7a, 1wxy, 1wxz, 2e1w, 2z7g – bADA + Zn + inhibitor
3ewc – PvADA + Zn + inhibitor
3ewd – PvADA (mutant) + Zn + inhibitor
3pbm – PaADA + Zn + chloropurine
Adenosine deaminase complex with protein
1w1i – bADA + Zn + dipeptidyl peptidase IV
2bgn – bADA + Zn + dipeptidyl peptidase IV + HIV1 TAT protein peptide
Double-stranded RNA-specific adenosine deaminase
1xmk – hADA Zα domain
1qgp – hADA Zα domain - NMR
2l54 – hADA Zα domain (mutant) - NMR
2mdr – hADA 3rd RNA-binding domain - NMR
1zy7 – hADA + inositol hexakisphosphate
2acj, 1qbj, 2gxb, 3f21, 3f22, 3f23, 3irq, 3irr – hADA Zα domain + DNA
2b7t, 2b7v – ADA – rat
tRNA-specific adenosine deaminase
1z3a – ADA – Escherichia coli
2b3j – ADA + Zn + tRNA stem-loop – Stapphylococcus aureus
