Deaminase

Deaminase removes an amine group from a molecule.

• Cytosine deaminase (CDA) converts cytosine to uracil.
  
• Cytidine deaminase (CDDA) converts cytidine to uridine.
  
• 5-methylcytosine deaminase (MCDA) produces thymine.
  
• Guanine deaminase (GDA) converts guanine to xanthine.
  
• Adenine deaminase (ADA) converts adenine to hypoxanthine.
  
• Glucosamine 6-phosphate deaminase (GPD) converts glucosamine 6-phosphate to fructose 6-phosphate.
  
• 1-aminocyclopropane-1-carboxylate deaminase (ACCD) converts 1-aminocyclopropane-1-carboxylic acid to 2-oxobutyrate.
  
• dCTP deaminase (ADA) converts dCTP to dUTP.
  
• dCTP deaminase-dUTPase (DCD-DUT) converts dCTP to dUMP.
  
• Blasticidin-S deaminase (BSD) converts blasticidin-S to deaminohydroxyblasticidin.
  
• Threonine deaminase (THD) converts L-threonine to α-ketobutyrate.
  
• L-serine deaminase (LSD) converts L-serine to pyruvate.
  
• D-serine deaminase (DSD) converts D-serine to pyruvate.
  

3D Structures of deaminase

Updated on 31-July-2014

Cytidine deaminase

1r5t – yCDA - yeast

2a8n – AtCDA – Agrobacterium tumefaciens
2g84 – CDA – Nitrosomonas europaea
2d30 – CDA – Bacillus anthracis
3dmo – CDA – Burkholderia pseudomallei
3ijf – MtCDA – Mycobacterium tuberculosis
3mpz – CDA – Mycobacterium smegmatis
3r2n – CDA – Mycobacterium leprae
4f3w – CDA – Mycobacterium marinum

Cytidine deaminase complex with nucleoside

1ctt – EcCDA + dihydro-pyrimidinone – Escherichia coli

1ctu – EcCDA + hydroxyl-dihydro-zebularine
1af2 – EcCDA + uridine
1aln – EcCDA + deazacytidine
1jtk – BsCDA + tetrahydrodeoxyuridine - Bacillus subtilis
1uwz, 1ux0, 1ux1 – BsCDA (mutant) + tetrahydrodeoxyuridine
1mq0 – hCDA + β-ribofuranosyl diazepinone - human
1zab – mCDA + deazauridine - mouse
2fr5 – mCDA + tetrahydrouridine
2fr6 – mCDA + cytidine + uridine
4eg2 – CDA + uridine - Vibrio cholerae

Cytosine deaminase

1k6w – EcCDDA

1r9x, 1r9y, 1r9z, 1ra0, 1ra5, 3g77 – EcCDDA (mutant)
1rb7, 1uaq – yCDDA
1ysb, 1ysd – yCDDA (mutant)

Cytosine deaminase complex

3r0d – EcCDDA + Zn

3rn6 – EcCDDA + Zn + iso-guanine
1k70 – EcCDDA + pyrimidine derivative
1rak – EcCDDA (mutant) + pyrimidine derivative
3o7u – EcCDDA + Zn + phosphono-cytosine
1ox7 – yCDDA + Zn
1p6o – yCDDA + pyrimidine derivative
2o3k – yCDDA (mutant) + pyrimidine derivative

Guanine deaminase

1tiy, 1wkq – BsGDA

3e0l – hGDA

Guanine deaminase complex with nucleoside

2i9u – GDA + guanine – Clostridium acetobutylicum

2ood – GDA + guanine – Bradrhizobium japonicum
2uz9 – hGDA + xanthine
4aql – hGDA + valacyclovir

Adenine deaminase

2ics – ADA - Enterococcus faecalis

3nqb, 3t81, 3t8l – AtADA

Adenosine deaminase

See Adenosine deaminase

Glucosamine 6-phosphate deaminase

1dea, 1cd5, 1fs6, 1fsf – EcGPD

1jt9 – EcGPD (mutant)
2ri0 – SmGPD – Streptococcus mutans
3hns – GPD – Borrelia burgdorferi
1hor – EcGPD + deoxy-amino glucitol-phosphate
1hot, 1frz, 1fs5, 2wu1 – EcGPD + N-acetyl-glucosamine-6-phosphate
1fqo – EcGPD + fructose 6-phosphate
2ri1 – SmGPD + glucosamine-6-phosphate

1-aminocyclopropane-1-carboxylate (ACC) deaminase

1f2d – WsACCD + PLP – Williopsis saturnus

1j0c – WsACCD (mutant) + PLP
1j0d – WsACCD (mutant) + inhibitor
1j0e – WsACCD (mutant) + PLP + ACC
1j0a – PhACCD + PLP + 2-propanol – Pyrococcus horikoshii
1j0b – PhACCD + inhibitor
1tyz – PsACCD + PLP - Pseudomonas
1rqx – PsACCD + PLP + inhibitor
1tz2 – PsACCD + PLP + ACC
1tzj – PsACCD + PLP + vinylglycine
1tzk – PsACCD + PLP + α-ketobutyrate
1tzm – PsACCD + PLP + chloroalanine

dCTP deaminase

2qlp – MtCTPD

3km3 – CTPD – Anaplasma phagocytophilum
4dhk – CTPD - Burkholderia thailandensis

dCTP deaminase complex

1xs1 – EcCTPD + dUTP

1xs4 – EcCTPD (mutant) + dCTP
2j4h – EcCTPD (mutant) + dCDP
1xs6, 2v9x – EcCTPD (mutant) + dUTP
2j4q – EcCTPD (mutant) + dTTP + dTDP
2qxx – MtCTPD + dTTP

dCTP deaminase-dUTPase

2hxb, 1ogh, 1pkh, 3gf0 – MjDCD-DUT – Methanocaldococcus jannaschii

1pkj – MjDCD-DUT + dUTP
2hxd – MjDCD-DUT (mutant) + dUTP derivative
1pkk – MjDCD-DUT + dCTP

Porphobilinogen deaminase

See Porphobilinogen Deaminase

Blasticidin-S deaminase

1wn5, 2z3g – AtBSD – Aspergillus terreus

2z3j – AtBSD (mutant)
3oj6 – BSD – Coccidioides immitis
1wn6 – AtBSD + blasticidin-S intermediate
2z3h – AtBSD + deaminohydroxy blasticidin-S
2z3i – AtBSD (mutant) + blasticidin-S

Threonine deaminase

1tdj – EcTHD + PLP

2gn0, 2gn1 – StTHD + PLP derivative – Salmonella typhimurium
2gn2 – StTHD + PLP derivative + CMP
3iau – THD + PLP derivative – tomato

L-serine deaminase

1pwe – rLSD - rat

1p5j, 2rkb – hLSD (mutant) + PLP
1pwh – rLSD + PLP derivative

D-serine deaminase

3r0x, 3r0z – DSD – Salmonella enterica

3ss7, 3ss9 – EcDSD + PLP