Function
Glutaminyl cyclase (QC) catalyzes the conversion of glutaminyl-peptide to 5-oxoprolyl-peptide and ammonia. Thus QC catalyzes the cyclization of an N-terminal glutamyl residue. QC acts on the generation of N-terminal pyroglutamyl groups of peptide hormones and amyloid-related plaque-forming peptides. The latter contributes to Alzheimer disease.
Disease
Relevance
QC is considered as a marker of thyroid tumors.
Structural highlights
3D Structures of glutaminyl cyclase
Updated on 31-July-2014
2afm, 2afo – hQC – human
3nok – QC – Myxococcus xanthus
2afs, 2zed, 2zee, 2zef, 2zeg, 2zeh, 2zel, 2zem, 2zen, 2zeo, 2zep, 3pbe – hQC (mutant)
3si1 –mQC – mouse
Glutaminyl cyclase complex
2afu – hQC + glutamine t-butyl ester
2afw – hQC + N-acetylhistamine
2afx, 3si0, 2afz – hQC + imidazole derivative
3pbb – hQC + inhibitor
3si2 – mQC + inhibitor
References
