Function
Ectonucleoside triphosphate diphosphohydrolase (NTPDase) hydrolyzes nucleoside 5’-triphosphate to nucleoside 5’-phosphate and 2 phosphates. NTPDase can hydrolyze ATP and ADP. NTPDase has an important role in regulating neutrophil chemotaxis. NTPDase 1,2,3,8 are cell surface enzymes with catalytic sites facing extracellularly while other NTPDases act intracellularly. NTPDase require Ca+2 or Mg+2 for their activity. The NTPDases can be differentiated according to their substrate specificity, divalent cation usage and product formation.
Disease
Relevance
Structural highlights
3D structures of ectonucleoside triphosphate diphosphohydrolase
Updated on 11-August-2014
NTPDase1
3aap – LpNTPDase – Legionella pneumophila
3aaq – LpNTPDase + inhibitor
3aar – LpNTPDase + AMPPNP
3zx3 – rNTPDase extracellular domain - rat
3zx0, 3zx2 – rNTPDase extracellular domain + polyoxometallates
4jep – TgNTPDase – Toxoplasma gondii
4a5b – TgNTPDase (mutant)
4kh6 – TgNTPDase (mutant) + adenosine-imido-diphosphate
NTPDase1 open form
4br4, 4brm – LpNTPDase
4br7, 4brc – LpNTPDase + adenosine-imido-diphosphate
NTPDase1 closed form
4br9 – LpNTPDase
4bra – LpNTPDase + AMPPNP
4brc – LpNTPDase + adenosine-imido-diphosphate
4brd – LpNTPDase (mutant) + AMPPNP
4bre – LpNTPDase + adenosine-5’-phosphovanadate
4brh – LpNTPDase + thyamine-5’-phosphovanadate
4brl – LpNTPDase + guanosine-5’-phosphovanadate
4brf, 4brn – LpNTPDase + AMP
4brg – LpNTPDase + GMPPNP
4bri – LpNTPDase + UMPPNP
4brk – LpNTPDase (mutant) + UMPPNP
4brq – LpNTPDase + AMP + phosphate
NTPDase1 part-open form
4bro – LpNTPDase
4bvp, 4bvo – LpNTPDase + polyoxometallates
NTPDase2
3cj1 – rNTPDase extracellular domain
3cj7 – rNTPDase extracellular domain + AMP
3cj9 – rNTPDase extracellular domain + AMP + phosphate
3cja – rNTPDase extracellular domain + AMPPNP
4bqz – rNTPDase extracellular domain + GMPPNP
4br2 – rNTPDase extracellular domain + UMPPNP
4br0 – rNTPDase extracellular domain + adenosine-imido-diphosphate
4cd1 – rNTPDase extracellular domain + inhibitor
4cd3 – rNTPDase extracellular domain (mutant) + inhibitor
NTPDase3
4a57 – TgNTPDase
4a59 – TgNTPDase + AMP
4a5a, 4kh4 – TgNTPDase (mutant) + AMPPNP
4kh5 – TgNTPDase (mutant) + adenosine-imido-diphosphate
References
