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Cyclin-dependent kinase
From Proteopedia
Template:STRUCTURE 3rgf Cyclin-dependent kinase (CDK) are serine/threonine kinases which are important to the regulation of the cell cycle. CDKs are small proteins which contain just a kinase domain. In order to function, CDK binds the regulatory protein cyclin. CDKs phosphorylate their substrates at a consensus tetrapeptide. The CDK classes differ by the binding cyclin and their function in human. For details on CDK2 see Cell Division Protein Kinase 2. CDK3 binds cyclin C and functions during the G1 phase. For details on CDK4 see Cyclin Dependent Kinase-4. CDK5 binds p53 and functions during transcription. CDK6 binds cyclin D and functions during the G1 phase. CDK8 binds cyclin C and functions during transcription. CDK9 facilitates the transition from abortive to productive transcription elongation by phosphorylating the C-terminal domain of the large subunit of RNA polymerase. CDK12 is required for RNA splicing.
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3D structures of cyclin-dependent kinase
Updated on 12-August-2014
CDK2 Cell Division Protein Kinase 2
CDK3
1fpz – hCDK3 (mutant)
CDK4 Cyclin Dependent Kinase-4
CDK5
1h4l – hCDK5 + CDK5 activator
1ung, 1unh, 1unl - hCDK5 (mutant) + CDK5 activator + inhibitor
3o0g - hCDK5 + ATP analog + CDK5 activator
CDK6
1bi7 – hCDK6 + multiple tumor suppressor
1bi8, 1blx – hCDK6 + CDK protein inhibitor
1g3n – hCDK6 + cyclin D homolog + CDK protein inhibitor
1jow – hCDK6 + V-cyclin
3nup, 3nux, 4aua, 4ez5 – hCDK6 + inhibitor
1xo2, 2f2c, 2euf, 4tth – hCDK6 + V-cyclin + inhibitor
CDK7
1ua2 – hCDK7
CDK8
4g6l – hCDK8 + cyclin C
3rgf, 4f6s, 4f6u, 4f6w, 4f70, 4f7j, 4f7l, 4f7n – hCDK8 + cyclin C + inhibitor
4f7s – hCDK8 + cyclin C + phenylethyl-quinazolin-amine
CDK9
3blh, 4ec8, 4ec9 – hCDK9-P + cyclin T1 (mutant)
3blq – hCDK9-P + cyclin T1 (mutant) + ATP
3lq5, 3my1, 3tn8, 3tnh, 3tni, 4bcf, 4bcg, 4bch, 4bci, 4bcj – hCDK9-P + cyclin T1 (mutant) + inhibitor
3blr – hCDK9-P + cyclin T1 + flavopiridol
3mi9, 3mia – hCDK9-P + cyclin T1 + HIV-1 TAT
4or5, 4ogr – hCDK9-P + cyclin T1 + HIV-1 TAT + major CDK9 elongation factor-associated protein
4imy – hCDK9-P + cyclin T1 + CDK9 elongation factor-associated protein
CDK12
4cjy, 4un0 – hCDK12-P + cyclin K
4nst – hCDK12-P + cyclin K + AlF3
4cxa – hCDK12-P + cyclin K + AMPPNP
CDK16
3mtl – hCDK16 (mutant) + indirubin
