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1bwm
From Proteopedia
Revision as of 09:39, 13 August 2014 by OCA (Talk | contribs)
1bwm is a 1 chain structure with sequence from Mus musculus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Using NMR spectroscopy, we determined the solution structure of a single-chain T-cell receptor (scTCR) derived from the major histocompatibility complex (MHC) class II-restricted D10 TCR. The conformations of complementarity-determining regions (CDRs) 3beta and 1alpha and surface properties of 2alpha are different from those of related class I-restricted TCRs. We infer a conserved orientation for TCR V(alpha) domains in complexes with both class I and II MHC-peptide ligands, which implies that small structural variations in V(alpha) confer MHC class preference. High mobility of CDR3 residues relative to other CDR or framework residues (picosecond time scale) provides insight into immune recognition and selection mechanisms.
Structure, specificity and CDR mobility of a class II restricted single-chain T-cell receptor.,Hare BJ, Wyss DF, Osburne MS, Kern PS, Reinherz EL, Wagner G Nat Struct Biol. 1999 Jun;6(6):574-81. PMID:10360364[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
↑ Hare BJ, Wyss DF, Osburne MS, Kern PS, Reinherz EL, Wagner G. Structure, specificity and CDR mobility of a class II restricted single-chain T-cell receptor. Nat Struct Biol. 1999 Jun;6(6):574-81. PMID:10360364 doi:10.1038/9359
