Exportin

Function

Exportins (XPO) mediate the nuclear export of cellular proteins with a leucine-rich export signal (NES) and RNA. XPO is regulated by GTPaseRan. RanGTP bind to XPO forming a ternary complex with the exported protein. The complex diffuses through the nuclear core complex to the cytoplasm and then dissociates. XPO-t exports tRNA from the nucleus.

Disease

Relevance

Structural highlights

3D structures of exportin

Updated on 18-August-2014

XPO-1

4bsm, 4bsn – hXPO – human
1w9c – hXPO C terminal 6 heat repeats
3vyc – yXPO (mutant) - yeast

XPO-1 complexes

3gb8 – hXPO + RNA U transporter 1

3gjx – hXPO + RNA U transporter 1 + GTPaseRan
3m1i, 4gpt, 4gmx, 4hat, 4hb2 – yXPO (mutant) + GTP-binding nuclear protein + Ran-specific GTPase-activating protein
4hau, 4hav, 4haw, 4hax, 4hay, 4haz, 4hb0, 4hb3, 4hb4 – yXPO (mutant) + GTP-binding nuclear protein + Ran-specific GTPase-activating protein + antibiotic
3nby, 3nbz, 3nc0 – mXPO + RNA U transporter 1 + GTPaseRan - mouse
3nc1 – mXPO + GTPaseRan
2l1l – hXPO residues 504-630 + cAMP-dependent protein kinase inhibitor α - NMR

XPO-t

3ibv – fyXPO – fission yeast
3icq – fyXPO + GTP-binding nuclear protein + RNA

XPO-5

3a6p – hXPO + peptide + pre-microRNA

References