Methylesterase
From Proteopedia
Template:STRUCTURE 3uw0
Methylesterase (ME) removes a methyl group from the Υ-glutamyl methyl esther residues of methyl-accepting chemotaxis proteins. ME participates in several metabolic pathways. Protein phosphatase ME is involved in the reversible methylation of protein phosphatase 2A which is active in cellular regulation.
- CheB ME is a phosphorylation-activated response regulator involved in reversible modification of bacterial chemotaxis receptors.
- Pectin ME causes demethylation of cell wall polygalactorunanas. It is involved in pectin digestion. The reaction products liberate frothing agents causing bloating in cattle.
- Aclacinomycin ME modifies the aklavinone skeleton in the biosynthesis of anthracyclins in Streptomyces species.
- Protein phosphatase ME is a key regulator of protein phosphatase 2A.
- 4-o-methyl-glucuronoyl ME has a significant role in biomass degradation.
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3D structures of methylesterase
Updated on 19-August-2014
CheB methylesterase
1chd, 1a2o – ME – Salmonella typhimurium
3sft – TmME catalytic domain – Thermotoga maritima
3t8y – TmME response regulator domain
Pectin methylesterase
1qjv – EcME – Erwinia chrysanthemi
1gq8 – ME – carrot
3uw0 – ME – Yersinia enterocolitica
1xg2 – ME + protein inhibitor – Solanum lycopersicum
2nsp, 2nst, 2nt6, 2nt9 – EcME (mutant) + hexasaccharide
2ntp, 2ntb, 2ntq – EcME + hexasaccharide
Aclacinomycin methylesterase
1q0r, 1q0z – ME + product analog – Streptomyces purpurascens
Protein phosphatase methylesterase
3c5v – hME1 – human
3c5w – hME1 + protein phosphatase 2A
4-o-methyl-glucuronoyl methylesterase
4g4g – MtME – Myceliophthora thermophila
4g4i – MtME (mutant)
4g4j – MtME (mutant) + 4-o-methyl-β-D-glucopyranuronate
