Mitogen-activated protein kinase kinase kinase

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Image:2clq.png
Crystal Structure of the Mitogen-activated protein kinase kinase kinase, 2clq

Template:STRUCTURE 2o2v

















Mitogen-activated protein kinase kinase kinase (MAP3K) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAP3K is part of the MAPK cascade which consists also of MAPK and MAP2K which are activated by phosphorylation. MAP3K activates MAP2K.

Contents

3D Structures of Mitogen-activated protein kinase kinase

Updated on 19-August-2014

MAP3K1

1uti - MAP3K1+GRB2-related adaptor protein 2 - mouse

MAP3K2

2cu1 - hMAP3K2 PB1 domain (mutant) - human - NMR
2o2v, 1p38 – hMAP3K2+hMAP3K5 - human
2npt - hMAP3K2 PHOX domain + hMAP2K5 PHOX domain

MAP3K3

2c60 – hMAP3K3 PHOX domain
2jrh - hMAP3K3 PB1 domain
2pph - hMAP3K3 PB1 domain - NMR

MAP3K5

2clq – hMAP3K5
4bf2, 4bhn, 4bib, 4bic, 4bid, 4bie - hMAP3K5 (mutant) + inhibitor

MAP3K7

2eva – hMAP3K7/MAP3K7-interacting protein

MAP3K9

3dtc - hMAP3K9 (mutant) + inhibitor

MAP3K10

2rf0 - hMAP3K10 SH3 domain - NMR

MAP3K14

4dn5 - hMAP3K14 (mutant) + ATP-γ-S
4idt, 4idv - hMAP3K14 + inhibitor

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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