Protein phosphatase

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 3k7v

Protein phosphatases (PP) regular protein phosphorylation and thus are key in intracellular signal transduction processes. PP1 is a serine/threonine phosphatase. PP2A targets proteins in the oncogenic signaling pathways. PP2C are Mg/Mn- dependent and are essential for the regulation of cell cycle and stress signaling pathways. PP4 regulates a variety of cellular functions. PP5 is activated by lipids and is involved in signal transduction. For PP2A see also HEAT Repeat.

Contents 1 3D Structures of protein phosphatase 1.1 PP1A 1.2 PP2A 1.3 PP2C 1.4 PP5

3D Structures of protein phosphatase

Updated on 20-August-2014

PP1A

3fxj, 3fxk, 3fxl, 3fxm, 3fxo – hPP1A + Mn – human
4da1 – hPP1K + Mn
1jk7, 1u32, 2bcd, 2bdx, 3e7a, 3e7b – hPP1 catalytic subunit + tumor-inducing toxin
1fjm – PP1 + tumor-inducing toxin - rabbit
3egg – hPP1 catalytic subunit + spinophilin
3hvq – hPP1 catalytic subunit + neuroabin
3n5u – hPP1A catalytic subunit + retinoblastoma-associated protein
3v4y – hPP1A catalytic subunit + PP1 nuclear inhibitor
4g9j – hPP1A catalytic subunit + peptide
3egh – hPP1 catalytic subunit + spinophilin + toxin
1it6 – hPP1 catalytic subunit + calyculin
1s70 – hPP1 catalytic subunit (mutant) + smooth muscle myosin phosphatase
2o8a, 2o8g – PP1C catalytic subunit + inhibitor - rat
2rlt – PP1 regulatory subunit – pig - NMR

PP2A

1b3u, 2ixm, 2jak, 2g62 – hPP2A regulatory subunit
2pkg – hPP2A regulatory subunit + small T antigen
2pf4 – PP2A regulatory subunit + small T antigen - mouse
2ie3, 2ie4, 2npp, 2nyl, 2nym, 2iae, 3dw8, 3k7v, 3k7w – hPP2A catalytic + regulatory subunit + tumor-inducing toxin
3fga – hPP2C catalytic + regulatory subunit + tumor-inducing toxin + Sgo
3c5w – hPP2A catalytic + regulatory subunit + PP2A-specific methyltransferase
3c5w, 3p71 – hPP2A catalytic subunit + leucine carboxyl methyltransferase

PP2C

1a6q – hPP2C
2iq1 – hPP2C κ
2p8e – hPP2C β
2cm1 – PP2C + Mn – Micobacterium tuberculosis
3d8k – PP2C – Toxoplasma gondii
3jrq, 3kdj, 3nmn – AtPP2C + Pyl1 – Arabidopsis thaliana
3nmt, 3kb3, 3nmv, 3ujl – AtPP2C + Pyl2
4la7, 4lg5, [4lga]], 4lgb – AtPP2C + Pyl2 + ligand
4ds8 – AtPP2C + Pyl3 + Mn
3rt0 – AtPP2C (mutant) + Pyl10
4n0g – AtPP2C + Pyl13
3qn1, 3zvu – AtPP2C + Pyr1
3ujg – AtPP2C + SNRK2
3ujk – AtPP2C

PP5

1s95 – hPP5 catalytic domain
2g62 – hPP5
2bug – hPP5 tetratricopeptide domain + Hsp90 peptide
3h60 – hPP5 catalytic domain + Mn
3h61, 3h62, 3h63, 3h64 – hPP5 catalytic domain + Mn + inhibitor
3h66 – hPP5 catalytic domain + Zn
3h67, 3h68, 3h69 – hPP5 catalytic domain + Zn + inhibitor