Pyrin domain
From Proteopedia
Pyrin domain (PYD) is a protein domain known as death fold. This domain allows the protein to interact with other pyrin domains. It is also known as PYD or PAAD/DAPIN or marenostrin domain. Proteins containing pyrin domain are involved in inflammation and apoptosis. The NALP proteins contain domains NACHT, LRR and PYD and are part of the inflammasome. A 781-amino acid protein named pyrin contains a PYD domain in its N-terminal. Mutations in the protein are the cause of Familial Mediterranean fever.
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3D Structures of Pyrin domain
2km6 – hPYD in NLRP7 – human – NMR
2wl1 – hPYD PRYSPRY residues 586-776
2do9 – mPYD in NALP10 – mouse – NMR
2yu0 – mPYD in interferon-activable protein 205 - NMR
1pn5 – hPYD in NALP1 - NMR
1ucp - hPYD in apoptosis-associated speck-like protein – NMR
2hm2 – hPYD in apoptosis-associated speck-like protein2 – NMR
2dbg – hPYD in myeloid cell nuclear differentiation antigen - NMR
