Transcriptional activator

spinqualitylabelsall models Structure of transcriptional activator C-Myb DNA-binding domain (pink) complex with DNA, CAAT/enhancer binding protein β (grey and green) and K+ ion (purple) (PDB entry 1h89) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Transcriptional activators (TA) are proteins which bind to DNA and stimulate nearby gene transcription. TA transcription stimulation is achieved by enhancing RNA polymerase binding or by enhancing the formation of open complex which is required for initiation of transcription. TA bind to a specific DNA sequence in or near an operon via their DNA-binding domain (DBD). TA contains 3 domains: DBD, trans-activating domain (TAD) which binds coregulator proteins and an optional ligand-binding domain (LBD) which sense external signals.

Contents 1 3D Structures of transcriptional activator 1.1 Gcn4 TA 1.2 Gcn5 TA 1.3 C-Myb TA 1.4 Psp operon TA 1.5 TenA TA 1.6 LasR TA 1.7 CadC TA 1.8 CynR TA 1.9 Mal-Rpel TA 1.10 Brg1 TA 1.11 VP30 TA 1.12 TraR TA 1.13 Flagelar TA 1.14 TipA TA 1.15 MtaN TA 1.16 RfaH TA 1.17 SoxR TA 1.18 AmpR TA 1.19 GlxR TA 1.20 OxyR TA 1.21 PlcR TA 1.22 VirB TA 1.23 MafA TA 1.24 CysB TA 1.25 HlyU TA 1.26 Aft2 TA

3D Structures of transcriptional activator

Updated on 21-August-2014

Gcn4 TA

See Gcn4

Gcn5 TA

1e6i – yTA brododomain + histone H4 peptide - yeast
1ygh – yTA histone acetyltransferase domain

C-Myb TA

1mse, 1msf – TA DBD + DNA - NMR
1mbe, 1mbf – mTA DBD repeat 1 + DNA – mouse - NMR
1mbg, 1mbh – mTA DBD repeat 2 + DNA - NMR
1mbj, 1mbk – mTA DBD repeat 3 + DNA - NMR
1h88 – mTA DBD + DNA + CCAAT/enhancer binding protein β
1h89 – mTA DBD + DNA + CAAT/enhancer binding protein β
1guu – mTA DBD repeat 1
1gv2 – mTA DBD repeat 2,3
1gv5 – mTA DBD repeat 2
1gvd – mTA DBD repeat 2 (mutant)
1idy, 1idz – mTA DBD repeat 3 (mutant) - NMR
1sb0, 2agh – mTA TAD + CREB-binding protein - NMR

Psp operon TA

2bjw – EcTA AAA domain – Escherichia coli
2bjv, 2c9c – EcTA AAA domain (mutant)
2c96 – EcTA AAA domain + ATP
2c98 – EcTA AAA domain + ADP
2c99 – EcTA AAA domain + AMPPNP
2vii – EcTA AAA domain + AMP + Mg

TenA TA

1tyh, 1yaf – BsTA – Bacillus subtilis
2qzc – TA – Sulfolobus solfataricus
3no6 – TA – Staphylococcus epidermidis
1yak – BsTA + pyrimidine derivative
2qcx – BsTA (mutant) + pyrimidine derivative

LasR TA

2uv0 – PaTA LBD – Pseudomonas aeruginosa
3ix3 – PaTA LBD + oxo-dodecanoyl-homoserine lactone
3ix4, 3ix8, 3jpu – PaTA LBD + benzoate derivative
4ng2 – PaTA LBD + protein

CadC TA

3ly7, 3lya – EcTA periplasmic domain
3ly8, 3ly9 – EcTA periplasmic domain (mutant)

CynR TA

2hxr – EcTA LBD
3hfu – EcTA LBD + N3

Mal-Rpel TA

2v51, 2v52 – mTA residues 16-41 + actin
2yje, 2yjf – mTA Rpel domain + actin

Brg1 TA

3uvd – TA bromodomain + pyrrolidone derivative - human

VP30 TA

2i8b – TA C terminal – Zaire ebolavirus
3v7o – TA C terminal – Reston ebolavirus

TraR TA

1l3l – AtTA + pheromone + DNA – Agrobacterium tumefaciens
1h0m – AtTA + auto-inducer + DNA

Flagelar TA

1g8e – EcTA FLHD
2avu – EcTA FLHC+FLHD

TipA TA

1ny9 – SlTA antibiotic binding domain – Streptomyces lividans - NMR
2vz4 – SlTA DBD + DNA

MtaN TA

1r8d – BsTA

RfaH TA

2oug – EcTA
2lcl – EcTA C terminal - NMR

SoxR TA

2zhh – EcTA
2zhg – EcTA + DNA

AmpR TA

3kos – CfTA effector binding domain – Citrobacter freundii
3kot – CfTA effector binding domain (mutant)

GlxR TA

3r6s – TA +cAMP – Corynebacterium glutamicum

OxyR TA

3t22 – TA regulatory domain – Porphyromonas gingivalis

PlcR TA

4fsc – BtTA - Bacillus thuringiensis
3u3w – BtTA + DNA + PAPR peptide

VirB TA

3vwb, 3w2a, 3w3c – TA core domain + DNA – Shigella flexneri

MafA TA

4eot – hTA DBD

CysB TA

4gwo, 4gxa – TA C terminal – Salmonella typhimurium

HlyU TA

4k2e – TA - Vibrio cholerae

Aft2 TA

4lmg – yTA + DNA