Tumor necrosis factor receptor

Function

Tumor necrosis factor receptor (TNFR) or death receptor is a trimeric cytokine receptor which binds TNF. TNFR family contains several members and superfamily (TNFRSF) members. The extracellular domain of TNFR contains 2 to 6 cysteine-rich domains. TNFRSF 6 is called Fas; TNFRSF 10B is called Dr5; TNFRSF 21 is called Dr6; TNFRSF 11A is called RANK; TNFRSF 18 is called GITRL.

Disease

Relevance

Structural highlights

3D structures of tumor necrosis factor receptor

Updated on 21-August-2014

TNFR-1

1ncf – hTNFR-1 residues 12-172 (mutant) – human
1ich – hTNFR-1 death domain (mutant) - NMR
2eqp – hTNFR-1 residues 28-70 – NMR
1ext – hTNFR-1 extracellular domain
1ft4 – hTNFR-1 extracellular domain + inhibitor
3on9 – evTNFR SECRET domain – ectromelia virus
3ona – evTNFR SECRET domain + CX3CL1

TNFRSF-1B

3alq – hTNFRSF-1B extracellular domain + TNF

TNFRSF-6 (Fas)

3thm, 3tje – hTNFRSF-6 extracellular domain + antibody
3ezq – hTNFRSF-6 Fas DD domain + FADD
3oq9 – mTNFRSF-6 Fas DD domain + FADD - mouse

TNFRSF-6B

3mhd – hTNFRSF-6B extracellular domain
4msv – hTNFRSF-6B extracellular domain + hTNFRSF-6 extracellular domain
4kgg, 4kgq, 4j6g – hTNFRSF-6B extracellular domain + hTNFRSF-14 extracellular domain
3mi8 – hTNFRSF-6B extracellular domain + hTNFRSF-15 extracellular domain
3k51 – hTNFRSF-6B cysteine-rich domain + hTNFRSF-15 extracellular domain

TNFRSF-10B (Dr5)

2h9g, 4od2, 1za3 – hTNFRSF-10B extracellular domain + antibody
1d0g – hTNFRSF-10B extracellular domain + apoptosis-2 ligand
1d4v – hTNFRSF-10B extracellular domain + TNF-related apoptosis inducing ligand

TNFRSF-11A (RANK)

3me4 – mTNFRSF-11A extracellular domain
4giq, 3qbq, 3me2 – mTNFRSF-11A extracellular domain + RANKL

TNFRSF-12A

2rpj – hTNFRSF-12A cysteine-rich domain – NMR

TNFRSF-18 (GITRL)

4db5 – TNFRSF-18 – rabbit
4e4s – TNFRSF-18 – pika
4g4f – TNFRSF-18 – bushbaby
3fc0, 2qdn, 3b9i – mTNFRSF-18
2q1m – hTNFRSF-18 extracellular domain
2r30, 2r32 – hTNFRSF-18 extracellular domain (mutant)

TNFRSF-21 (Dr6)

3u3p, 3u3q, 3u3s, 3u3t, 3u3v – hTNFRSF-21 cysteine-rich domain
2dbh – hTNFRSF-21 CARD-like domain - NMR
3qo4 – hTNFRSF-21 residues 42-218

References