6-phosphogluconate dehydrogenase

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Template:STRUCTURE 1pgj 6-phosphogluconate dehydrogenase (6PDH) catalyzes the decarboxylation reduction of 6-phosphogluconate (6PG) to ribulose 5-phosphate and CO2. This reaction is part of the pentose phosphate pathway. NADP is a cofactor in this reaction and is converted to NADPH.

1 3D structures of 6-phosphogluconate dehydrogenase

3D structures of 6-phosphogluconate dehydrogenase

Updated on 21-August-2014

6PDH

2pgd - s6PDH – sheep
1pgj - 6PDH – Trypanosoma brucei
2p4q - 6PDH – yeast
2zyg - 6PDH (mutant) – Klebsiella pneumonia
4e21 - Gm6PDH – Geobacter metallireducens 4gbj – Df6PDH – Dyadobacter fermentans
4gwg - h6PDH – human

6PDH binary complex

1pgn – s6PDH + Br-NADP
1pgo - s6PDH + NADP
1pgp - s6PDH + 6PG
1pgq - s6PDH + AMP
2jkv - h6PDH + NADP
4gwk - h6PDH + 3PG
2zya - Ec6PDH (mutant) + 6PG – Escherichia coli
2w8z, 2w90 - 6PDH + 6PG – Geobacillus stearothermophilus
2iyo - Ll6PDH + 6PG – Lactococcus lactis
2zyd - Ec6PDH (mutant) + glucose

6PDH ternary complex

2iz1 - Ll6PDH + inhibitor + ADP
3fwn - Ec6PDH (mutant) + ADP + 6PG
3pef – Gm6PDH (mutant) + NADP + monophosphoadenosine diphosphoribose
3w6u – Pc6PDH + NADP + monophosphoadenosine diphosphoribose – Pyrobaculum calidifontis
3w6z – Pc6PDH (mutant) + NADP + monophosphoadenosine diphosphoribose