This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Aldehyde dehydrogenase
From Proteopedia
Aldehyde dehydrogenase (ALDH) converts aldehydes to carboxylic acids while reducing NAD+ to NADH. In mammals there are 3 classes of ALDH and each contain constitutive and inducible forms. Class 1 is cytosolic; class 2 mitochondrial; class 3 found in tumors, stomach and cornea. ALDH family 7 member A1 is known as antiquitin and functions in the detoxification of aldehydes.
Contents |
3D Structures of Aldehyde dehydrogenase
Updated on 24-August-2014
ALDH class 1
3fx4 – ALDH1 + NADP + inhibitor – pig
1bxs – ALDH1 - sheep
1o9j – ALDH1 + NAD – Elephant shrew
3rhj, 3rhl, 3rho, 3rhp, 3rhq, 3rhr – rALDH1 C- terminal (mutant) + NADP – rat
3rhm - rALDH1 C- terminal
1hso – hALDH1 α subunit + Zn + NAD
1ht0 – hALDH1 γ subunit (mutant) + Zn + NAD
ALDH class 2
3n80, 1o05 – hALDH2 residues 18-517- human
3n81, 2onn, 2ono, 1zum – hALDH2 residues 18-517 (mutant)
1ag8 – bALDH NAD binding domain - bovine
Binary complex
3inj, 3inl - hALDH2 residues 18-517 + agonist
2vle - hALDH2 residues 24-517 + daidzin
1nzx, 1nzz, 1o00, 1o02, 1cw3 - hALDH2 residues 18-517 + NAD
3n82, 3n83, 2onm, 2onp, 1nzw, 1o04 – hALDH2 residues 18-517 (mutant) + NADH
3sz9 - hALDH2 residues 18-517 + inhibitor
1a4z – bALDH2 NAD-binding domain + NAD
Ternary complex
1o01 - hALDH2 residues 18-517 + NADH + aldehyde
4fqf - hALDH2 residues 18-517 + NAD + NO2
4fr8 - hALDH2 residues 18-517 (mutant) + NAD + ADP + nitroglycerin
ALDH class 3
1ad3 – rALDH
3sza - hALDH
3qj5, 3szb – hALDH + inhibitor
4h80 - hALDH (mutant) + inhibitor
NAD-dependent ALDH
2w8n, 2w8o, 2w8r – Succinate–semi-hALDH family 5
2w8p - Succinate–semi-hALDH family 5 (mutant)
3r31 – Betaine-ALDH – Agrobacterium tumefaciens
3ed6, 4mpb, 4nu9 - Betaine-SaALDH – Staphylococcus aureus
1a4s - Betaine-cALDH - cod
3llg, 3tz6, 3vos – Aspartate-semi-MtALDH
2cq8 - Formyltetrahydrofolate-hALDH PP-binding domain - NMR
2nac – Formate-PsALDH
3i44 – ALDH – Bartonella henselae
3ek1 – ALDH – Brucella melitensis
3ros – ALDH – Lactobacillus acidophilus
3r64 – ALDH – Corynebacterium glutamicum
3rhe – Benzaldehyde-ALDH – Legionella pneumophila
3u4j, 4i3t – SmALDH – Sinorhizobium meliloti
Binary complexes
2w8q - Succinate–semi-hALDH family 5 + succinic acid
3fg0, 4mpy, 4nea - Betaine-SaALDH + NAD
4ni4 - Betaine-SaALDH (mutant) + NAD
1bpw - Betaine-cALDH + NAD
2j6l – Aminoadipate-semi-hALDH family 7 + NAD
2cfi - Formyltetrahydrofolate-hALDH hydrolase domain + formyltetrahydropterin
2nad - Formate-PsALDH + NAD – Pseudomonas
1bi9 – Retinal-rALDH2 + NAD
3l4p, 1sij – ALDH + AsO3 – Desulfovibrio gigas
4a0m – spALDH + NAD – spinach
3iwk – amino-ALDH + NAD – pea
3ju8 - Succinylglutamic–semi-PaALDH + NAD – Pseudomonas aeruginosa
4c3s - ALDH + NAD – Clostridium phytofermentans
4i3u – SmALDH + phosphonoacetaldehyde
Ternary complexes
2gsd – Formate-ALDH + NAD + azide – Moraxella
1nvm – Acetaldehyde-PsALDH + 4-hydroxy-oxovalerate aldolase + NAD
1llu - PaALDH + NAD + alcohol
4i3v, 4i3w – SmALDH + aldehyde derivative + NAD
4i3x – SmALDH + phosphonoacete + NAD
NADP-dependent ALDH
3k2w - Betaine-ALDH – Pseudoalteromonas atlantica
2hg2, 2opx – Lactaldehyde-EcALDH
2o2p – Formyltetrahydrofolate-rALDH C-terminal
2y51, 2y52, 2y53, 2y5d – BxALDH (mutant) – Burkholderia xenovorans
3ifg, 3ifh - Succinate–semi-ALDH – Burkholderia pseudomallei
3rh9 - Succinate–semi-ALDH – Marinobacter aquaeolei
3uw3 - aspartate–semi-ALDH – Burkholderia thailandensis
3v4c - SmALDH
Binary complexes
2wox, 2wme, 2xdr, 3zqa - Betaine-PaALDH + NADP
3lv1 – Benzaldehyde-PpALDH3 + NADP – Pseudomonas putida
2ilu - Lactaldehyde-EcALDH + NADP
3rhd - Lactaldehyde-MjALDH + NADP - Methanocaldococcus jannaschii
2o2q, 2o2r - Formyltetrahydrofolate-rALDH C-terminal + NADP
3b4w - MtALDH + NADP – Mycobacterium tuberculosis
1eyy, 1ez0 – ALDH + NADP – Vibrio harveyi
3jz4 - Succinate–semi-EcALDH + NADP
3hsk - aspartate–semi-ALDH + NADP – Candida albicans
4h73 - ALDH + NADP – Pyrobaculum
Ternary complexes
3lns - Benzaldehyde-PpALDH3 + NADP + benzoate
2imp - Lactaldehyde-EcALDH + NADH + lactate
2vro – BxALDH + NADP + alcohol
3k9d – ALDH – Listeria monocytogenes
Antiquitin
2jg7 – Antiquitin – Acanthopagrus schlegeli
3my7 – ALDH – Vibrio parahaemolyticus
