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1cww
From Proteopedia
Revision as of 09:21, 27 August 2014 by OCA (Talk | contribs)
1cww is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Activation of procaspase-9, a key component of the apoptosis mechanism, requires the interaction of its caspase recruitment domain (CARD) with the CARD in the adaptor protein Apaf-1. Using nuclear magnetic resonance spectroscopy and mutagenesis we have determined the structure of the CARD from Apaf-1 and the residues important for binding the CARD in procaspase-9. Apaf-1's CARD contains seven short alpha-helices with the core six helices arranged in an antiparallel manner. Residues in helix 2 have a central role in mediating interaction with procaspase-9 CARD. This interaction surface is distinct from that proposed based on the structure of the CARD from RAIDD, but is coincident with that of the structurally similar FADD death effector domain and the Apaf-1 CARD interface identified by crystallographic studies.
Solution structure and mutagenesis of the caspase recruitment domain (CARD) from Apaf-1.,Day CL, Dupont C, Lackmann M, Vaux DL, Hinds MG Cell Death Differ. 1999 Nov;6(11):1125-32. PMID:10578182[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
↑ Day CL, Dupont C, Lackmann M, Vaux DL, Hinds MG. Solution structure and mutagenesis of the caspase recruitment domain (CARD) from Apaf-1. Cell Death Differ. 1999 Nov;6(11):1125-32. PMID:10578182 doi:10.1038/sj.cdd.4400584
