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Phosphoglycerate dehydrogenase

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Human phosphoglycerate dehydrogenase dimer complex with malate and cofactor NAD 2g76

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Phosphoglycerate dehydrogenase (PGDH) catalyzes the conversion of 3-phosphoglycerate into 3-phosphohydroxypyruvate. This is the first step of serine biosynthesis. NAD is used as cofactor. In some cancer cells there is an elevation in PGDH level.

1 3D structures of phosphoglycerate dehydrogenase

3D structures of phosphoglycerate dehydrogenase

PDGH

1ygy, 3dc2 – MtPGDH – Mycobacterium tuberculosis
3evt - PGDH – Lactobacillus plantarum
3gg9 - PGDH – Ralstonia solanacearum
3k5p - PGDH (mutant) – Brucella melitensis

PGDH binary complex

1sc6, 2p9c, 2p9e, 2p9g - EcPGDH (mutant) + NAD – Escherichia coli
1yba - EcPGDH + NAD
1wwk - PGDH + NAD – Pyrococcus horikoshii
2g76 - PGDH + NAD – human
2ekl - PGDH + NAD – Sulfolobus tokodaii
3ddn - MtPGDH + hydroxypyruvic acid phosphate