This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1dc0
From Proteopedia
Revision as of 06:31, 4 September 2014 by OCA (Talk | contribs)
The DNA dodecamer CATGGGCCCATG in a crystal structure of resolution 1.3 A has a conformation intermediate between A and B DNA. This trapping of a stable intermediate suggests that the A and B DNA families are not discrete, as previously believed. The structure supports a base-centered rather than a backbone-centered mechanism for the A <--> B transition mediated by guanine tracts. Interconversion between A and B DNA provides another means for regulating protein-DNA recognition.
The structure of a stable intermediate in the A <--> B DNA helix transition.,Ng HL, Kopka ML, Dickerson RE Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2035-9. PMID:10688897[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
↑ Ng HL, Kopka ML, Dickerson RE. The structure of a stable intermediate in the A <--> B DNA helix transition. Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2035-9. PMID:10688897 doi:http://dx.doi.org/10.1073/pnas.040571197
