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1dc0
From Proteopedia
Revision as of 06:31, 4 September 2014 by OCA (Talk | contribs)
The DNA dodecamer CATGGGCCCATG in a crystal structure of resolution 1.3 A has a conformation intermediate between A and B DNA. This trapping of a stable intermediate suggests that the A and B DNA families are not discrete, as previously believed. The structure supports a base-centered rather than a backbone-centered mechanism for the A <--> B transition mediated by guanine tracts. Interconversion between A and B DNA provides another means for regulating protein-DNA recognition.
The structure of a stable intermediate in the A <--> B DNA helix transition.,Ng HL, Kopka ML, Dickerson RE Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2035-9. PMID:10688897[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
↑ Ng HL, Kopka ML, Dickerson RE. The structure of a stable intermediate in the A <--> B DNA helix transition. Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2035-9. PMID:10688897 doi:http://dx.doi.org/10.1073/pnas.040571197
