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1dj8
From Proteopedia
Revision as of 06:37, 4 September 2014 by OCA (Talk | contribs)
1dj8 is a 6 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
The X-ray crystal structure of the Escherichia coli stress response protein HDEA has been determined at 2.0 A resolution. The single domain alpha-helical protein is found in the periplasmic space, where it supports an acid resistance phenotype essential for infectivity of enteric bacterial pathogens, such as Shigella and E. coli. Functional studies demonstrate that HDEA is activated by a dimer-to-monomer transition at acidic pH, leading to suppression of aggregation by acid-denatured proteins. We suggest that HDEA may support chaperone-like functions during the extremely acidic conditions.
HDEA, a periplasmic protein that supports acid resistance in pathogenic enteric bacteria.,Gajiwala KS, Burley SK J Mol Biol. 2000 Jan 21;295(3):605-12. PMID:10623550[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
↑ Gajiwala KS, Burley SK. HDEA, a periplasmic protein that supports acid resistance in pathogenic enteric bacteria. J Mol Biol. 2000 Jan 21;295(3):605-12. PMID:10623550 doi:http://dx.doi.org/10.1006/jmbi.1999.3347
