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3k4v
From Proteopedia
Revision as of 05:33, 24 September 2014 by OCA (Talk | contribs)
3k4v is a 4 chain structure with sequence from Hiv-1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Protein carbamylation is of great concern both in vivo and in vitro. Here, we report the first structural characterization of a protein carbamylated at the N-terminal proline. The unexpected carbamylation of the alpha-amino group of the least reactive codified amino acid has been detected in high-resolution electron density maps of a new crystal form of the HIV-1 protease/saquinavir complex. The carbamyl group is found coplanar to the proline ring with a trans conformation. The reaction of N-terminal with cyanate ion derived from the chaotropic agent urea was confirmed by mass spectra analysis on protease single crystals. Implications of carbamylation process in vitro and in vivo are discussed.
Carbamylation of N-terminal proline.,Olajuyigbe FM, Demitri N, Ajele JO, Maurizio E, Randaccio L, Geremia S ACS Med Chem Lett. 2010 Jun 2;1(6):254-7. doi: 10.1021/ml100046d. eCollection, 2010 Sep 9. PMID:24900204[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
↑ Olajuyigbe FM, Demitri N, Ajele JO, Maurizio E, Randaccio L, Geremia S. Carbamylation of N-terminal proline. ACS Med Chem Lett. 2010 Jun 2;1(6):254-7. doi: 10.1021/ml100046d. eCollection, 2010 Sep 9. PMID:24900204 doi:http://dx.doi.org/10.1021/ml100046d
