This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1edn
From Proteopedia
Revision as of 11:19, 24 September 2014 by OCA (Talk | contribs)
1edn is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
The three-dimensional structure of the vasoactive polypeptide endothelin, the most potent vasoconstrictor yet identified, has been determined by X-ray crystallography to 2.18 A resolution. This intermediate-sized structure was solved by molecular replacement techniques using a fragment of an NMR-derived model for initial phasing of the data. However, comparisons of the final X-ray structure with the many diverse models derived from NMR data indicate some important differences, especially in the carboxy-terminal region of the molecule: the entire carboxy terminal tail (residues 16-21) is helical in the crystal structure, but not in any of the NMR structures. This may be a functionally significant difference as this region is crucial for receptor binding and vasoactivity.
The crystal structure of human endothelin.,Janes RW, Peapus DH, Wallace BA Nat Struct Biol. 1994 May;1(5):311-9. PMID:7664037[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
↑ Janes RW, Peapus DH, Wallace BA. The crystal structure of human endothelin. Nat Struct Biol. 1994 May;1(5):311-9. PMID:7664037
