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Involucrin is a key component of the cross-linked envelope of terminally differentiated keratinocytes. The human molecule largely consists of 10 residue repeats and forms a thin 460 A long rod. Summarized experimental data and a detailed stereochemical analysis made with computer modeling resulted in a structural model for the involucrin molecule. The suggested structure is a left-handed alpha-helical solenoid built of a tandem array of helix-turn-helix folds. The structure enables us to explain the whole set of experimental data and residue conservations within the repeats. It is ideally suited to serve as a scaffold for cell envelope assembly and proposes a possible mode of the intermolecular interactions of involucrin during cell cornification.
alpha-Helical solenoid model for the human involucrin.,Kajava AV FEBS Lett. 2000 May 12;473(2):127-31. PMID:10812058[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
↑ Kajava AV. alpha-Helical solenoid model for the human involucrin. FEBS Lett. 2000 May 12;473(2):127-31. PMID:10812058
