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1isn
From Proteopedia
Revision as of 09:09, 28 September 2014 by OCA (Talk | contribs)
1isn is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Neurofibromatosis type 2 (NF2) is a dominantly inherited disease associated with the central nervous system. The NF2 gene product merlin is a tumor suppressor, and its mutation or inactivation causes this disease. We report here the crystal structure of the merlin FERM domain containing a 22-residue alpha-helical segment. The structure reveals that the merlin FERM domain consists of three subdomains displaying notable features of the electrostatic surface potentials, although the overall surface potentials similar to those of ezrin/radixin/moesin (ERM) proteins indicate electrostatic membrane association. The structure also is consistent with inactivation mechanisms caused by the pathogenic mutations associated with NF2.
Structural basis for neurofibromatosis type 2. Crystal structure of the merlin FERM domain.,Shimizu T, Seto A, Maita N, Hamada K, Tsukita S, Tsukita S, Hakoshima T J Biol Chem. 2002 Mar 22;277(12):10332-6. Epub 2001 Dec 27. PMID:11756419[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
↑ Shimizu T, Seto A, Maita N, Hamada K, Tsukita S, Tsukita S, Hakoshima T. Structural basis for neurofibromatosis type 2. Crystal structure of the merlin FERM domain. J Biol Chem. 2002 Mar 22;277(12):10332-6. Epub 2001 Dec 27. PMID:11756419 doi:10.1074/jbc.M109979200
