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1iou
From Proteopedia
Revision as of 09:36, 28 September 2014 by OCA (Talk | contribs)
1iou is a 1 chain structure with sequence from Saccharomyces cerevisiae. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Ykt6p is a nonsyntaxin SNARE implicated in multiple intracellular membrane trafficking steps. Here we present the structure of the NH2-terminal domain of Ykt6p (Ykt6pN, residues 1 to 140). The structure of Ykt6pN differed entirely from that of syntaxin and resembled the overall fold of the actin regulatory protein, profilin. Like some syntaxins, Ykt6p adopted a folded back conformation in which Ykt6pN bound to its COOH-terminal core domain. The NH2-terminal domain plays an important biological role in the function of Ykt6p, which in vitro studies revealed to include influencing the kinetics and proper assembly of SNARE complexes.
An autoinhibitory mechanism for nonsyntaxin SNARE proteins revealed by the structure of Ykt6p.,Tochio H, Tsui MM, Banfield DK, Zhang M Science. 2001 Jul 27;293(5530):698-702. PMID:11474112[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
↑ Tochio H, Tsui MM, Banfield DK, Zhang M. An autoinhibitory mechanism for nonsyntaxin SNARE proteins revealed by the structure of Ykt6p. Science. 2001 Jul 27;293(5530):698-702. PMID:11474112 doi:10.1126/science.1062950
