We have complemented multiple sequence alignments of the lectin domains of the selectins with an analysis of structurally invariant regions in X-ray structures of the mannose-binding protein (MBP) and E-selectin. The analysis shows that regions of structural conservation between MBP and E-selectin extend beyond regions of rigorous sequence conservation within the selectin family and suggests that reliable three-dimensional models of selectins from different species can be generated by modification of only a few backbone segments in E-selectin. A model of the L-selectin lectin domain is built and discussed with regard to observed differences in selectin specificity.
A template for generation and comparison of three-dimensional selectin models.,Bajorath J, Aruffo A Biochem Biophys Res Commun. 1995 Nov 22;216(3):1018-23. PMID:7488174[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
↑ Bajorath J, Aruffo A. A template for generation and comparison of three-dimensional selectin models. Biochem Biophys Res Commun. 1995 Nov 22;216(3):1018-23. PMID:7488174 doi:http://dx.doi.org/10.1006/bbrc.1995.2722
