Tryptophan synthase
From Proteopedia
Tryptophan synthase (TrpS) is an α2β2 tetramer participating in the biosynthesis of tryptophan. TrpS α subunit catalyzes the formation of indole and glyceraldehyde-3-phosphate (G3P) from indole-3-glycerol phosphate (IGP). The β subunit catalyzes in a pyridoxal-phosphate (PLP) dependent reaction the formation of tryptophan (Trp) from indole and serine. The diffusion of indole from the α to the β subunit is facilitated via a hydrophobic channel connecting the subunits. TrpS is not found in animals hence it is tested as a possible drug target for tubertculosis, ocular and genital infections, cryptosporidiosis and as herbicide.
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3D structures of tryptophan synthase
Updated on 28-September-2014
TrpS α subunit
3vnd - TrpS α subunit – Shewanella frigidimarina
3tha - TrpS α subunit – Campylobacter jejuni
3nav - TrpS α subunit – Vibrio cholerae
1geq - PfTrpS α subunit - Pyrococcus furiosus
2dzp, 2dzs, 2dzt, 2dzu, 2dzv, 2dzw, 2dzx, 2e09 - PfTrpS α subunit (mutant)
1rd5 - TrpS α subunit – corn
1ujp - TtTrpS α subunit
1v7y, 1wq5, 1xc4 - EcTrpS α subunit
1xcf - EcTrpS α subunit (mutant)
2ekc - TrpS α subunit – Aquifex aeolicus
TrpS α binary complex
1wxj - TtTrpS α subunit + indole propanol phosphate
TrpS β subunit
1x1q - TtTrpS β subunit – Thermus thermophilus
2dh6 - EcTrpS β subunit]] - Escherichia coli
2o2e, 2o2j - TrpS β subunit – Mycobacterium tuberculosis
1v8z - PfTrpS β subunit
4neg - TrpS β subunit – Bacillus anthracis
TrpS β binary complex
2dh5 - EcTrpS β subunit + PLP
TrpS α+β subunits
1wdw - PfTrpS α + β subunits
TrpS α+β binary complex
1ttp, 1ttq, 1bks, 2wsy, 1kfk - StTrpS α + β + PLP – Salmonella typhimurium
1a5a, 1k8x - StTrpS α (mutant) + β + PLP
1k7x, 2j9z - StTrpS α + β (mutant) + PLP
2tys - StTrpS α (mutant) + β (mutant) + Trp derivative
1kfe - StTrpS α (mutant) + β + pyridoxal-serine-monophsphate
1kfj - StTrpS α + β + pyridoxal-serine-monophsphate
2j9y - StTrpS α + β (mutant) + enoic acid derivative
3pr2 - StTrpS α + β + inhibitor
4hn4, 4hpj, 4hpx, 4ht3, 4kkx - TrpS α + β + inhibitor – Salmonella enterica
TrpS α+β ternary complex with PLP and inhibitor
1a50, 1cw2, 1c9d, 1cx9, 1c8v, 1c29, 2cle, 2clh, 2cli, 2clk, 2cll, 2clm, 2clo, 2clf - StTrpS α + β + inhibitor + PLP
1fuy - StTrpS α + β (mutant) + inhibitor + PLP
TrpS α+β ternary complex with PLP and IGP derivatives
1a5b, 1kfb - StTrpS α (mutant) + β + IGP + PLP
1k8z - StTrpS α + β (mutant) + IGP derivative + PLP
1kfc - StTrpS α (mutant) + β + IGP derivative + PLP
1k3u, 1k7e, 1k7f - StTrpS α + β + IGP derivative + PLP
1qoq, 2rh9, 2rhg - StTrpS α + β + IGP + PLP
1qop - StTrpS α + β + IGP analog + PLP
2trs, 1beu - StTrpS α (mutant) + β (mutant) + pyridoxal-serine-monophsphate + IGP analog
TrpS α+β ternary complex with PLP and G3P derivatives
1wbj - StTrpS α + β + G3P + PLP
2j9x - StTrpS α + β + G3P + acrylic acid derivative
1k8y - StTrpS α + β (mutant) + G3P derivative + PLP
1tjp - StTrpS α + β + G3P derivative + PLP
2tsy - StTrpS α (mutant) + β (mutant) + pyridoxal-serine-monophsphate + G3P
1ubs - StTrpS α (mutant) + β (mutant) + serine + PLP
TrpS α+β quaternary complex
1a5s - StTrpS α + β + serine + inhibitor + PLP
3cep - StTrpS α + β + G3P + indoline + PLP
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Amer Ali
