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1f5q
From Proteopedia
Revision as of 13:15, 28 September 2014 by OCA (Talk | contribs)
1f5q is a 4 chain structure with sequence from Homo sapiens and Murid herpesvirus 4. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Several gamma-herpesviruses encode proteins related to the mammalian cyclins, regulatory subunits of cyclin-dependent kinases (cdks) essential for cell cycle progression. We report a 2.5 A crystal structure of a full-length oncogenic viral cyclin from gamma-herpesvirus 68 complexed with cdk2. The viral cyclin binds cdk2 with an orientation different from cyclin A and makes several novel interactions at the interface, yet it activates cdk2 by triggering conformational changes similar to cyclin A. Sequences within the viral cyclin N-terminus lock part of the cdk2 T-loop within the core of the complex. These sequences and others are conserved amongst the viral and cellular D-type cyclins, suggesting that this structure has wider implications for other cyclin-cdk complexes. The observed resistance of this viral cyclin-cdk complex to inhibition by the p27(KIP:) cdk inhibitor is explained by sequence and conformational variation in the cyclin rendering the p27(KIP:)-binding site on the cyclin subunit non-functional.
Crystal structure of a gamma-herpesvirus cyclin-cdk complex.,Card GL, Knowles P, Laman H, Jones N, McDonald NQ EMBO J. 2000 Jun 15;19(12):2877-88. PMID:10856233[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
↑ Card GL, Knowles P, Laman H, Jones N, McDonald NQ. Crystal structure of a gamma-herpesvirus cyclin-cdk complex. EMBO J. 2000 Jun 15;19(12):2877-88. PMID:10856233 doi:10.1093/emboj/19.12.2877
