| Structural highlights
1ocn is a 1 chain structure with sequence from Humicola insolens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Ligands: | , , ,
| | Related: | 1bvw, 1gz1, 1hgw, 1hgy, 1oc5, 1oc6, 1oc7, 1ocb, 1ocj, 1qjw, 1qk0, 1qk2, 2bvw |
| Activity: | Cellulose 1,4-beta-cellobiosidase, with EC number 3.2.1.91 |
| Resources: | FirstGlance, OCA, RCSB, PDBsum |
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
A cellobio-derived isofagomine glycosidase inhibitor (Ki approximately 400 nM) displays an unusual distorted 2,5B (boat) conformation upon binding to cellobiohydrolase Cel6A from Humicola insolens, highlighting the different conformational itineraries used by various glycosidases, with consequences for the design of therapeutic agents.
Distortion of a cellobio-derived isofagomine highlights the potential conformational itinerary of inverting beta-glucosidases.,Varrot A, Macdonald J, Stick RV, Pell G, Gilbert HJ, Davies GJ Chem Commun (Camb). 2003 Apr 21;(8):946-7. PMID:12744312[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Varrot A, Macdonald J, Stick RV, Pell G, Gilbert HJ, Davies GJ. Distortion of a cellobio-derived isofagomine highlights the potential conformational itinerary of inverting beta-glucosidases. Chem Commun (Camb). 2003 Apr 21;(8):946-7. PMID:12744312
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