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1mmj
From Proteopedia
Revision as of 13:57, 28 September 2014 by OCA (Talk | contribs)
1mmj is a 1 chain structure with sequence from Sus scrofa. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The crystal structure of porcine pancreatic elastase (PPE) complexed with a potent peptidyl inhibitor, FR136706, was solved at 2.2A resolution. FR136706 fits snugly into the extended active site pocket. The benzene moiety of FR136706 induced dramatic movement of the side chain moiety of Arg217 and both moieties formed a pi-pi interaction, which has never been found previously in structures of PPE complexed with inhibitors. This novel interaction mode may lead to design of new types of inhibitors.
True interaction mode of porcine pancreatic elastase with FR136706, a potent peptidyl inhibitor.,Kinoshita T, Nakanishi I, Sato A, Tada T Bioorg Med Chem Lett. 2003 Jan 6;13(1):21-4. PMID:12467609[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
↑ Kinoshita T, Nakanishi I, Sato A, Tada T. True interaction mode of porcine pancreatic elastase with FR136706, a potent peptidyl inhibitor. Bioorg Med Chem Lett. 2003 Jan 6;13(1):21-4. PMID:12467609
