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1kna
From Proteopedia
Revision as of 14:07, 28 September 2014 by OCA (Talk | contribs)
1kna is a 2 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The chromodomain of the HP1 family of proteins recognizes histone tails with specifically methylated lysines. Here, we present structural, energetic, and mutational analyses of the complex between the Drosophila HP1 chromodomain and the histone H3 tail with a methyllysine at residue 9, a modification associated with epigenetic silencing. The histone tail inserts as a beta strand, completing the beta-sandwich architecture of the chromodomain. The methylammonium group is caged by three aromatic side chains, whereas adjacent residues form discerning contacts with one face of the chromodomain. Comparison of dimethyl- and trimethyllysine-containing complexes suggests a role for cation-pi and van der Waals interactions, with trimethylation slightly improving the binding affinity.
Structure of HP1 chromodomain bound to a lysine 9-methylated histone H3 tail.,Jacobs SA, Khorasanizadeh S Science. 2002 Mar 15;295(5562):2080-3. Epub 2002 Feb 21. PMID:11859155[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
↑ Jacobs SA, Khorasanizadeh S. Structure of HP1 chromodomain bound to a lysine 9-methylated histone H3 tail. Science. 2002 Mar 15;295(5562):2080-3. Epub 2002 Feb 21. PMID:11859155 doi:10.1126/science.1069473
