| Structural highlights
1mqd is a 4 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Ligands: | , ,
| | Related: | 1ftj, 1ftk, 1ftl, 1ftm, 1fto, 1fw0, 1gr2, 1lbb, 1lbc, 1lb8, 1lb9, 1m5b, 1m5c, 1m5d, 1m5e, 1m5f, 1mm6, 1mm7 |
| Resources: | FirstGlance, OCA, RCSB, PDBsum |
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
X-ray structures of the GluR2 ligand-binding core in complex with (S)-Des-Me-AMPA and in the presence and absence of zinc ions have been determined. (S)-Des-Me-AMPA, which is devoid of a substituent in the 5-position of the isoxazolol ring, only has limited interactions with the partly hydrophobic pocket of the ligand-binding site, and adopts an AMPA-like binding mode. The structures, in comparison with other agonist complex structures, disclose the relative importance of the isoxazolol ring and of the substituent in the 5-position for the mode of binding. A relationship appears to exist between the extent of interaction of the ligand with the hydrophobic pocket and the affinity of the ligand.
GluR2 ligand-binding core complexes: importance of the isoxazolol moiety and 5-substituent for the binding mode of AMPA-type agonists.,Kasper C, Lunn ML, Liljefors T, Gouaux E, Egebjerg J, Kastrup JS FEBS Lett. 2002 Nov 6;531(2):173-8. PMID:12417307[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Kasper C, Lunn ML, Liljefors T, Gouaux E, Egebjerg J, Kastrup JS. GluR2 ligand-binding core complexes: importance of the isoxazolol moiety and 5-substituent for the binding mode of AMPA-type agonists. FEBS Lett. 2002 Nov 6;531(2):173-8. PMID:12417307
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