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1lfp
From Proteopedia
Revision as of 15:56, 28 September 2014 by OCA (Talk | contribs)
1lfp is a 1 chain structure with sequence from Aquifex aeolicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The crystal structure of a conserved hypothetical protein, Aq1575, from Aquifex aeolicus has been determined by using x-ray crystallography. The protein belongs to the domain of unknown function DUF28 in the Pfam and PALI databases for which there was no structural information available until now. A structural homology search with the DALI algorithm indicates that this protein has a new fold with no obvious similarity to those of other proteins of known three-dimensional structure. The protein reveals a monomer consisting of three domains arranged along a pseudo threefold symmetry axis. There is a large cleft with approximate dimensions of 10 A x 10 A x 20 A in the center of the three domains along the symmetry axis. Two possible active sites are suggested based on the structure and multiple sequence alignment. There are several highly conserved residues in these putative active sites. The structure based molecular properties and thermostability of the protein are discussed.
Crystal structure of conserved hypothetical protein Aq1575 from Aquifex aeolicus.,Shin DH, Yokota H, Kim R, Kim SH Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7980-5. PMID:12060744[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
↑ Shin DH, Yokota H, Kim R, Kim SH. Crystal structure of conserved hypothetical protein Aq1575 from Aquifex aeolicus. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7980-5. PMID:12060744 doi:http://dx.doi.org/10.1073/pnas.132241399
