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1m55
From Proteopedia
Revision as of 17:41, 28 September 2014 by OCA (Talk | contribs)
1m55 is a 2 chain structure with sequence from Adeno-associated virus - 5. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Adeno-associated virus (AAV), unique among animal viruses in its ability to integrate into a specific chromosomal location, is a promising vector for human gene therapy. AAV Replication (Rep) protein is essential for viral replication and integration, and its amino terminal domain possesses site-specific DNA binding and endonuclease activities required for replication initiation and integration. This domain displays a novel endonuclease fold and demonstrates an unexpected structural relationship to other viral origin binding proteins such as the papillomavirus E1 protein and the SV40 T antigen. The active site, located at the bottom of a positively charged cleft, is formed by the spatial convergence of a divalent metal ion and two conserved sequence motifs that define the rolling circle replication superfamily.
Structural unity among viral origin binding proteins: crystal structure of the nuclease domain of adeno-associated virus Rep.,Hickman AB, Ronning DR, Kotin RM, Dyda F Mol Cell. 2002 Aug;10(2):327-37. PMID:12191478[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
↑ Hickman AB, Ronning DR, Kotin RM, Dyda F. Structural unity among viral origin binding proteins: crystal structure of the nuclease domain of adeno-associated virus Rep. Mol Cell. 2002 Aug;10(2):327-37. PMID:12191478
