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1qgt
From Proteopedia
Revision as of 20:09, 28 September 2014 by OCA (Talk | contribs)
1qgt is a 4 chain structure with sequence from Hepatitis b virus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Hepatitis B is a small enveloped DNA virus that poses a major hazard to human health. The crystal structure of the T = 4 capsid has been solved at 3.3 A resolution, revealing a largely helical protein fold that is unusual for icosahedral viruses. The monomer fold is stabilized by a hydrophobic core that is highly conserved among human viral variants. Association of two amphipathic alpha-helical hairpins results in formation of a dimer with a four-helix bundle as the major central feature. The capsid is assembled from dimers via interactions involving a highly conserved region near the C terminus of the truncated protein used for crystallization. The major immunodominant region lies at the tips of the alpha-helical hairpins that form spikes on the capsid surface.
The crystal structure of the human hepatitis B virus capsid.,Wynne SA, Crowther RA, Leslie AG Mol Cell. 1999 Jun;3(6):771-80. PMID:10394365[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
