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1t7k
From Proteopedia
Revision as of 20:29, 28 September 2014 by OCA (Talk | contribs)
1t7k is a 2 chain structure with sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
A series of novel azacyclic urea HIV protease inhibitors bearing a benzenesulfonamide group at P1' were synthesized utilizing a parallel synthesis method. Structural studies of early analogs bound in the enzyme active site were used to design more potent inhibitors. The effects of substituting the P1' benzenesulfonyl group on antiviral activity and protein binding are described.
Synthesis and antiviral activity of P1' arylsulfonamide azacyclic urea HIV protease inhibitors.,Huang PP, Randolph JT, Klein LL, Vasavanonda S, Dekhtyar T, Stoll VS, Kempf DJ Bioorg Med Chem Lett. 2004 Aug 2;14(15):4075-8. PMID:15225729[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
