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1oun
From Proteopedia
Revision as of 20:52, 28 September 2014 by OCA (Talk | contribs)
1oun is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Nuclear transport factor 2 (NTF2) facilitates protein transport into the nucleus and interacts with both the small Ras-like GTPase Ran and nucleoporin p62. We have determined the structure of bacterially expressed rat NTF2 at 1.6 angstroms resolution using X-ray crystallography. The NTF2 polypeptide chain forms an alpha + beta barrel that opens at one end to form a distinctive hydrophobic cavity and its fold is homologous to that of scytalone dehydratase. The NTF2 hydrophobic cavity is a candidate for a potential binding site for other proteins involved in nuclear import such as Ran and nucleoporin p62. In addition, the hydrophobic cavity contains a putative catalytic Asp-His pair, which raises the possibility of an unanticipated enzymatic activity of the molecule that may have implications for the molecular mechanism of nuclear protein import.
The 1.6 angstroms resolution crystal structure of nuclear transport factor 2 (NTF2).,Bullock TL, Clarkson WD, Kent HM, Stewart M J Mol Biol. 1996 Jul 19;260(3):422-31. PMID:8757804[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
↑ Bullock TL, Clarkson WD, Kent HM, Stewart M. The 1.6 angstroms resolution crystal structure of nuclear transport factor 2 (NTF2). J Mol Biol. 1996 Jul 19;260(3):422-31. PMID:8757804
