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1p9x
From Proteopedia
Revision as of 21:09, 28 September 2014 by OCA (Talk | contribs)
1p9x is a 1 chain structure with sequence from Deinococcus radiodurans. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
The crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribosomal subunit shows that telithromycin blocks the ribosomal exit tunnel and interacts with domains II and V of the 23S RNA. Comparisons to other clinically relevant macrolides provided structural insights into its enhanced activity against macrolide-resistant strains.
Structural insight into the antibiotic action of telithromycin against resistant mutants.,Berisio R, Harms J, Schluenzen F, Zarivach R, Hansen HA, Fucini P, Yonath A J Bacteriol. 2003 Jul;185(14):4276-9. PMID:12837804[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
↑ Berisio R, Harms J, Schluenzen F, Zarivach R, Hansen HA, Fucini P, Yonath A. Structural insight into the antibiotic action of telithromycin against resistant mutants. J Bacteriol. 2003 Jul;185(14):4276-9. PMID:12837804
