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1tou
From Proteopedia
Revision as of 22:35, 28 September 2014 by OCA (Talk | contribs)
1tou is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The synthesis and biological evaluation of novel human A-FABP inhibitors based on the 6-(trifluoromethyl)pyrimidine-4(1H)-one scaffold is described. Two series of compounds, bearing either an amino or carbon substituent in the 2-position of the pyrimidine ring were investigated. Modification of substituents and chain length optimization led to novel compounds with low micromolar activity and good selectivity for human A-FABP.
Substituted benzylamino-6-(trifluoromethyl)pyrimidin-4(1H)-ones: a novel class of selective human A-FABP inhibitors.,Ringom R, Axen E, Uppenberg J, Lundback T, Rondahl L, Barf T Bioorg Med Chem Lett. 2004 Sep 6;14(17):4449-52. PMID:15357970[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
↑ Ringom R, Axen E, Uppenberg J, Lundback T, Rondahl L, Barf T. Substituted benzylamino-6-(trifluoromethyl)pyrimidin-4(1H)-ones: a novel class of selective human A-FABP inhibitors. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4449-52. PMID:15357970 doi:10.1016/j.bmcl.2004.06.058
