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1tm6
From Proteopedia
Revision as of 23:24, 28 September 2014 by OCA (Talk | contribs)
1tm6 is a 1 chain structure with sequence from Escherichia coli. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
SecA is an integral component of the prokaryotic Sec preprotein secretory translocase system. We report here the solution NMR structure of a fragment corresponding to the C-terminal domain of Escherichia coli SecA. In the presence of Zn2+, the fragment adopts a shortened version of the classic betabetaalpha zinc finger fold. The isolated C-terminal domain shows substantial differences from the X-ray structure of a homologous SecA domain bound to the chaperone-like cofactor SecB. The differences between the structures of the free and bound forms suggest that binding to SecB causes a perturbation of the C-terminal domain's intrinsically favored betabetaalpha fold.
NMR structure of the C-terminal domain of SecA in the free state.,Matousek WM, Alexandrescu AT Biochim Biophys Acta. 2004 Nov 1;1702(2):163-71. PMID:15488768[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
↑ Matousek WM, Alexandrescu AT. NMR structure of the C-terminal domain of SecA in the free state. Biochim Biophys Acta. 2004 Nov 1;1702(2):163-71. PMID:15488768 doi:S1570-9639(04)00216-X
