| Structural highlights
2c3s is a 1 chain structure with sequence from Sars coronavirus. This structure supersedes the now removed PDB entry 2bw6. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Related: | 1o5s, 1p76, 1p9t, 1pa5, 1puk, 1q1x, 1uj1, 1uk2, 1uk3, 1uk4, 1uw7, 1wof, 2amd, 2amq, 2bx3, 2bx4, 2d2d |
| Resources: | FirstGlance, OCA, RCSB, PDBsum |
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The 34 kDa main proteinase (Mpro) from the severe acute respiratory syndrome coronavirus (SARS-CoV) plays an important role in the virus life cycle through the specific processing of viral polyproteins. As such, SARS-CoV Mpro is a key target for the identification of specific inhibitors directed against the SARS virus. With a view to facilitating the development of such compounds, crystals were obtained of the enzyme at pH 6.5 in the orthorhombic space group P2(1)2(1)2 that diffract to a resolution of 1.9 A. These crystals contain one monomer per asymmetric unit and the biologically active dimer is generated via the crystallographic twofold axis. The conformation of the catalytic site indicates that the enzyme is active in the crystalline form and thus suitable for structure-based inhibition studies.
Structure of the SARS coronavirus main proteinase as an active C2 crystallographic dimer.,Xu T, Ooi A, Lee HC, Wilmouth R, Liu DX, Lescar J Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Nov 1;61(Pt, 11):964-6. Epub 2005 Oct 20. PMID:16511208[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Xu T, Ooi A, Lee HC, Wilmouth R, Liu DX, Lescar J. Structure of the SARS coronavirus main proteinase as an active C2 crystallographic dimer. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Nov 1;61(Pt, 11):964-6. Epub 2005 Oct 20. PMID:16511208 doi:10.1107/S1744309105033257
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