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2gic
From Proteopedia
Revision as of 04:32, 29 September 2014 by OCA (Talk | contribs)
2gic is a 6 chain structure with sequence from Vesicular stomatitis indiana virus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Vesicular stomatitis virus is a negative-stranded RNA virus. Its nucleoprotein (N) binds the viral genomic RNA and is involved in multiple functions including transcription, replication, and assembly. We have determined a 2.9 angstrom structure of a complex containing 10 molecules of the N protein and 90 bases of RNA. The RNA is tightly sequestered in a cavity at the interface between two lobes of the N protein. This serves to protect the RNA in the absence of polynucleotide synthesis. For the RNA to be accessed, some conformational change in the N protein should be necessary.
Structure of the vesicular stomatitis virus nucleoprotein-RNA complex.,Green TJ, Zhang X, Wertz GW, Luo M Science. 2006 Jul 21;313(5785):357-60. Epub 2006 Jun 15. PMID:16778022[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
↑ Green TJ, Zhang X, Wertz GW, Luo M. Structure of the vesicular stomatitis virus nucleoprotein-RNA complex. Science. 2006 Jul 21;313(5785):357-60. Epub 2006 Jun 15. PMID:16778022
