Publication Abstract from PubMed
A novel series of 3-hydroxychromones were prepared and found to be CDK inhibitors. Isothiazolidine 1,1-dioxide analogues showed potent CDK1 and CDK2 inhibitory activities and inhibited proliferation of EJ, HCT116, SW620, and MDAMB468 cancer cells.
3-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation.,Lee J, Park T, Jeong S, Kim KH, Hong C Bioorg Med Chem Lett. 2007 Mar 1;17(5):1284-7. Epub 2006 Dec 15. PMID:17178224[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
